Hydrazine hydrate (1:1) → HCID 22288370, compound

HRID 968190Notes

Reaction equation

HRID 968190 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[N:7][N:6]=1>C(O)C>[ClH:4].[Cl:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:2][NH2:3])=[N:7][N:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 784901,4-Dichlorophthalazine

Product 1

HCID 22288370HCID 22288370, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a stirred solution of hydrazine hydrate (40 ml) in ethanol (120 mL) at 80° C. was added 1,4-dichlorophthalazine (20 g). This reaction, mixture was stirred at 80° C. for 0.5 hours, then left to cool and the product was collected by filtration and dried under vacuum to give 1-chloro-4-hydrazinophthalazine hydrochloride (14.6 g). 1H NMR (250 MHz, DMSO)•4.64 (2H, vbs), 7.2 (1H, vbs), 7.92 (4H, bm).

Workup

  1. customThis reaction, mixture
  2. waitleft
  3. temperatureto cool
  4. filtrationthe product was collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-1567ec331f6949c5aed70efc18ff2919
Source dataset
uspto-grants-2005_10
Patent number
US06958334B2

Reaction notes

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