2-Amino-2-methyl-1-propanol → 2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanol

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-2-methyl-1-propanol	HCID 11807	—
Reactant	5-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine	HCID 11278274	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanol	HCID 22288467	65.5%

Reaction Steps

The product from step (c) (0.6 g) and 2-amino-2-methylpropanol (1.1 g) in tetrahydrofuran (10 ml) was heated in a sealed vessel at 100° C. for 18 hours. The mixture was evaporated to dryness and purified (SiO2, ethyl acetate as eluant) to give the subtitle compound (0.46 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06958343B2
Source dataset	uspto-grants-2005_10
ORD ID	ord-382b3c799eca4ca8b94f747c8fe90405
Source note	uspto-grants-2005_10