2-Amino-2-methyl-1-propanol → 2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanol

HRID 968203Notes

Reaction equation

HRID 968203 reaction equation
Cl[C:2]1[C:3]2[S:18][C:17]([NH2:19])=[N:16][C:4]=2[N:5]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]=1.[NH2:20][C:21]([CH3:25])([CH3:24])[CH2:22][OH:23]>O1CCCC1>[NH2:19][C:17]1[S:18][C:3]2[C:2]([NH:20][C:21]([CH3:25])([CH3:24])[CH2:22][OH:23])=[N:7][C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:5][C:4]=2[N:16]=1

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 112782745-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine

Product 1

HCID 222884672-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanolYield 65.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from step (c) (0.6 g) and 2-amino-2-methylpropanol (1.1 g) in tetrahydrofuran (10 ml) was heated in a sealed vessel at 100° C. for 18 hours. The mixture was evaporated to dryness and purified (SiO2, ethyl acetate as eluant) to give the subtitle compound (0.46 g).

Workup

  1. customThe mixture was evaporated to dryness
  2. custompurified (SiO2, ethyl acetate as eluant)

Sources & evidence

ORD record
ord-382b3c799eca4ca8b94f747c8fe90405
Source dataset
uspto-grants-2005_10
Patent number
US06958343B2

Reaction notes

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