Dimethylformamide → HCID 135555956, compound

HRID 968210Notes

Reaction equation

HRID 968210 reaction equation
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[OH-].[Na+].O.Cl.[CH3:15][C:16]1[S:17][CH:18]=[CH:19][N:20]=1.[CH3:21]N(C=O)C>>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH2:21][C:19]2[N:20]=[C:16]([CH3:15])[S:17][CH:18]=2)[NH:6][C:7](=[O:9])[CH:8]=1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 22288455HCID 22288455, compoundHCID 178507962HCID 178507962, compound

Product 1

HCID 135555956HCID 135555956, compound

Procedure

4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate (0,161 g) and sodium hydroxide (0.08 g) were stirred in dry DMF (4 ml) for 20 mins. 4-Chloromethyl, 2-methylthiazole hydrochloride hydrate (0.2 g) was added and the mixture stirred for 3 hr then poured onto water (150 ml) to give a solution. The subtitled product crystallised and was collected, washed with water and dried (0.2 g).

Workup

  1. additionthen poured onto water (150 ml)
  2. customto give a solution
  3. customThe subtitled product crystallised
  4. customwas collected
  5. washwashed with water
  6. customdried (0.2 g)

Sources & evidence

ORD record
ord-cb95ad2322e448c480313bcbb2846621
Source dataset
uspto-grants-2005_10
Patent number
US06958343B2

Reaction notes

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