2-Amino-2-methyl-1,3-propanediol → HCID 178459839, compound

HRID 968239Notes

Reaction equation

HRID 968239 reaction equation
Br[C:2]1[N:10]=[C:9]([S:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[F:20])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([NH:21]C(=O)OCC)[NH:6]2.[NH2:27][C:28]([CH3:33])([CH2:31][OH:32])[CH2:29][OH:30]>>[NH2:21][C:5]1[NH:6][C:7]2[C:3]([N:4]=1)=[C:2]([NH:27][C:28]([CH3:33])([CH2:31][OH:32])[CH2:29][OH:30])[N:10]=[C:9]([S:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=1[F:20])[N:8]=2

Participants

3

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 178473456Ethyl 6-bromo-2-[(2,3-difluorobenzyl)thio]-9H-purin-8-ylcarbamate

Product 1

HCID 178459839HCID 178459839, compound

Procedure

The titled compound was prepared from the product of example 5, step (e) (50 mg) and 2-amino-2-methyl-1,3-propanediol (70 mg) using the method of example 5, step (f) and purified by preparative HPLC to yield a white solid.

Workup

  1. custompurified by preparative HPLC
  2. customto yield a white solid

Sources & evidence

ORD record
ord-86ffbdd0039a42f9a79329480c00edf0
Source dataset
uspto-grants-2005_10
Patent number
US06958344B2

Reaction notes

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