反应详情

To a solution of (3-amino-5-methylphenyl)methanol (1.0 g, 7.29 mmol) in CH2Cl2 (30 mL) was added BOC2O (1.75 g, 8.02 mmol) at room temperature. After 24 hours the mixture was concentrated. Flash column chromatography (30% EtOAc/hexanes) gave tert-butyl 3-(hydroxymethyl)-5-methylphenylcarbamate as a white solid. 1H-NMR (300 MHz, CDCl3) δ 7.20 (s, 1H), 7.18 (s, 1H), 6.85 (s, 1H), 6.45 (bs, 1H), 4.60 (s, 2H), 3.60 (bs, 2H), 2.32 (s, 3H), 1.50 (s, 9H).

1. concentrationAfter 24 hours the mixture was concentrated