Hydrogen Bromide → HCID 22288814, compound

HRID 968301Notes

Reaction equation

HRID 968301 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:4]=1[NH:10][C:11]1[NH:12][C:13]2[CH:19]=[C:18]([O:20]C)[CH:17]=[CH:16][C:14]=2[N:15]=1.[BrH:22]>C(O)(=O)C>[BrH:22].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:4]=1[NH:10][C:11]1[NH:12][C:13]2[CH:19]=[C:18]([OH:20])[CH:17]=[CH:16][C:14]=2[N:15]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 22288812HCID 22288812, compound

Product 1

HCID 22288814HCID 22288814, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.05 g of 2-(2,6-dichlorophenylamino)-5-methoxybenzimidazole hydrochloride, 0.5 ml of glacial acetic acid, and 0.5 ml of hydrobromic acid (48% strength) was boiled under reflux for 3 hours and the solvent was then distilled off. The solid residue was brought to crystallization under a little EA. 0.02 g of 2-(2,6-dichlorophenylamino)-5-hydroxybenzimidazole hydrobromide was obtained of melting point 265-269° C.

Workup

  1. temperatureunder reflux for 3 hours
  2. distillationthe solvent was then distilled off
  3. customThe solid residue was brought to crystallization under a little EA

Sources & evidence

ORD record
ord-732a7ab7f15c46e9aa8def2686aacca3
Source dataset
uspto-grants-2005_10
Patent number
US06958357B2

Reaction notes

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