Dichloromethane → 5-(5-amino-2-thienyl)-1-methyl-3-trifluoromethyl-1H-pyrazole hydrochloride

HRID 968320Notes

Reaction equation

HRID 968320 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[S:11][C:10]([NH:12]C(OC(C)(C)C)=O)=[CH:9][CH:8]=2)=[CH:5][C:4]([C:20]([F:23])([F:22])[F:21])=[N:3]1.FC(F)(F)C(O)=O.[Cl:31]CCl>>[ClH:31].[NH2:12][C:10]1[S:11][C:7]([C:6]2[N:2]([CH3:1])[N:3]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:5]=2)=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 22288380tert-butyl 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbamate

Product 1

HCID 222883925-(5-amino-2-thienyl)-1-methyl-3-trifluoromethyl-1H-pyrazole hydrochloride

Procedure

A mixture of tert-butyl 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbamate, trifluoroacetic acid and dichloromethane was stirred at room temperature for 2 days and then subjected to purification and salt formation in the usual way to give 5-(5-amino-2-thienyl)-1-methyl-3-trifluoromethyl-1H-pyrazole hydrochloride as light yellow powder crystals.

Workup

  1. customsubjected to purification and salt formation in the usual way

Sources & evidence

ORD record
ord-e87430892d764656801414f138b6f863
Source dataset
uspto-grants-2005_10
Patent number
US06958339B2

Reaction notes

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