HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 1,4-Dioxa-8-azaspiro[4.6]undecane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 1,4-dioxa-8-azaspiro[4.6]undecane-8-carboxylate | HCID 69282947 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1,4-Dioxa-8-azaspiro[4.6]undecane | HCID 21679591 | 62.7% |
Reaction Steps
A mixture of intermediate (4) (0.585 mol) and KOH (5.85 mol) in 2-propanol (1200 ml) was stirred and refluxed overnight. The solvent was evaporated. The residue was stirred in water and this mixture was extracted with DCM. The separated organic layer was dried, filtered, and the solvent evaporated, yielding 57.7 g of 1,4-dioxa-8-azaspiro[4.6]undecane (intermediate 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304052B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-0879ae058660484dbe63ef8f53bffb91 |
| Source note | uspto-grants-2007_12 |