反应详情

A mixture of intermediate (4) (0.585 mol) and KOH (5.85 mol) in 2-propanol (1200 ml) was stirred and refluxed overnight. The solvent was evaporated. The residue was stirred in water and this mixture was extracted with DCM. The separated organic layer was dried, filtered, and the solvent evaporated, yielding 57.7 g of 1,4-dioxa-8-azaspiro[4.6]undecane (intermediate 5).

1. temperaturerefluxed overnight
2. customThe solvent was evaporated
3. stirringThe residue was stirred in water
4. extractionthis mixture was extracted with DCM
5. customThe separated organic layer was dried
6. filtrationfiltered
7. customthe solvent evaporated