HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 968488Generated: October 28, 2026
Potassium Carbonate → hexahydro-1-[2-(4-methoxyphenyl)ethyl]-4H-azepin-4-one
https://huagongshe.com/reaction/968488
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-[2-(4-Methoxyphenyl)ethyl]-1,4-dioxa-8-azaspiro[4.6]undecane | HCID 69282949 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | hexahydro-1-[2-(4-methoxyphenyl)ethyl]-4H-azepin-4-one | HCID 69282946 | 93.2% |
Reaction Steps
A mixture of intermediate (6) (0.098 mol) in HCl (3 N, 300 ml) and THF (300 ml) was stirred at 60° C. for 1 hour. The mixture was basified with solid K2CO3 and extracted with ethyl acetate. The organic layer was separated, dried, filtered and the solvent was evaporated, yielding 22.6 g of hexahydro-1-[2-(4-methoxyphenyl)ethyl]-4H-azepin-4-one (intermediate 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07304052B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-2ae045344984407ca46a2b8df1f9ddfa |
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| Source note | uspto-grants-2007_12 |
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