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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 968536Generated: October 25, 2026

Benzoyl chloride → 1-Benzoyl-3-[2-methoxy-5-(tetrahydropyran-4-yl)-phenyl]-thiourea

https://huagongshe.com/reaction/968536

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzoyl chlorideHCID 7412—
ReactantAmthioHCID 13417437—
Reactant2-Methoxy-5-(tetrahydropyran-4-yl)-phenylamineHCID 21919262—
SolventAcetoneHCID 180—
Product1-Benzoyl-3-[2-methoxy-5-(tetrahydropyran-4-yl)-phenyl]-thioureaHCID 22719571—

Reaction Steps

To a solution of ammonium rhodanide in acetone is added benzoyl chloride and a solution of 2-methoxy-5-(tetrahydro-pyran-4-yl)-phenylamine (IX). The reaction is carried out under reflux for about 20 minutes. The product 1-benzoyl-3-[2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea (X) is isolated by conventional means.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07304058B2
Source datasetuspto-grants-2007_12
ORD IDord-2b9490f3c4f2427d83ad5bfd852d1b2f
Source noteuspto-grants-2007_12