HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-(3-Chlorophenyl)1-[5-(morpholine-4-carbonyl)-1H-pyrrol-3-yl]-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2,2,2-Trichloro-1-(4-(3-Chlorophenyl) acetyl-1H-pyrrol-2-yl)-ethanone | HCID 22713650 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3-Chlorophenyl)1-[5-(morpholine-4-carbonyl)-1H-pyrrol-3-yl]-ethanone | HCID 22713597 | — |
Reaction Steps
To a solution of compound 1 (1 equivalent) in DMF, at ambient temperature, was added morpholine (1.2 equivalents). After 24 hours, the solvent was evaporated and the crude product 4 was used without purification. FIA/MS (M+1) 333.3, (M−1) 331.2; 1H NMR was consistent with expected structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304061B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-63dd825f532340e091b193f38b0613de |
| Source note | uspto-grants-2007_12 |