Morpholine → 2-(3-Chlorophenyl)1-[5-(morpholine-4-carbonyl)-1H-pyrrol-3-yl]-ethanone

HRID 968546Notes

Reaction equation

HRID 968546 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([C:10](=[O:19])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[CH:9]=1)=[O:4].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>CN(C=O)C>[Cl:18][C:14]1[CH:13]=[C:12]([CH2:11][C:10]([C:8]2[CH:9]=[C:5]([C:3]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:4])[NH:6][CH:7]=2)=[O:19])[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 227136502,2,2-Trichloro-1-(4-(3-Chlorophenyl) acetyl-1H-pyrrol-2-yl)-ethanone

Product 1

HCID 227135972-(3-Chlorophenyl)1-[5-(morpholine-4-carbonyl)-1H-pyrrol-3-yl]-ethanone

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of compound 1 (1 equivalent) in DMF, at ambient temperature, was added morpholine (1.2 equivalents). After 24 hours, the solvent was evaporated and the crude product 4 was used without purification. FIA/MS (M+1) 333.3, (M−1) 331.2; 1H NMR was consistent with expected structure.

Workup

  1. customthe solvent was evaporated
  2. customthe crude product 4 was used without purification

Sources & evidence

ORD record
ord-63dd825f532340e091b193f38b0613de
Source dataset
uspto-grants-2007_12
Patent number
US07304061B2

Reaction notes

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