HCID 59015781, compound → HCID 59015784, compound

HRID 968555Notes

Reaction equation

HRID 968555 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])=[CH:7][C:6]=1[N+:21]([O-])=O)=[O:4].[H][H]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:18])([F:19])[F:20])=[CH:7][C:6]=1[NH2:21])=[O:4]

Participants

4

Reactant 2

HCID 59015781HCID 59015781, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59015784HCID 59015784, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

In a Parr apparatus, hydrogenate an ethanolic solution of 3-nitro-2′-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester (5.54 g, 0.0169 mol) under 55 psi of hydrogen using tetrakis(triphenylphosphine)palladium (0) (300 mg). After 18 hours, filter the mixture through celite and concentrate under reduced pressure to give 3-amino-2′-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester as a solid.

Workup

  1. filtrationfilter the mixture through celite
  2. concentrationconcentrate under reduced pressure

Sources & evidence

ORD record
ord-593e06b6179546af9368ef5b87b54aa3
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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