HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | HCID 22030371 | HCID 22030371 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 22030121 | HCID 22030121 | — |
Reaction Steps
Reflux a solution of 4-chloro-7-(2-trifluoromethyl-phenyl)-quinazoline (258 mg, 0.836 mmol) and 4-(trifluoromethyl)-aniline (269 mg, 1.67 mmol) in isopropyl alcohol for 8 hours. Cool the solution, collect the precipitate via filtration and wash with dry ether (3×) to give pure (4-Trifluoromethyl-phenyl)-[7-(2-trifluoromethyl-phenyl)-quinazolin-4-yl]amine (Cmpd 2) HCl salt. Mass spec. 433.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-987e265efc5c4448800fdf9c8a7b78cf |
| Source note | uspto-grants-2007_12 |