4-(Trifluoromethyl)aniline → Hydrochloric Acid

HRID 968558Notes

Reaction equation

HRID 968558 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[C:18]([F:21])([F:20])[F:19])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[CH:30]=[CH:29][C:27]([NH2:28])=[CH:26][CH:25]=1>C(O)(C)C>[F:22][C:23]([F:31])([F:32])[C:24]1[CH:25]=[CH:26][C:27]([NH:28][C:2]2[C:11]3[C:6](=[CH:7][C:8]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[C:18]([F:21])([F:20])[F:19])=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:29][CH:30]=1.[ClH:1]

Participants

5

Reactant 2

HCID 99644-(Trifluoromethyl)anilineHCID 22030371HCID 22030371, compound

Product 2

HCID 313Hydrochloric AcidHCID 22030121HCID 22030121, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Reflux a solution of 4-chloro-7-(2-trifluoromethyl-phenyl)-quinazoline (258 mg, 0.836 mmol) and 4-(trifluoromethyl)-aniline (269 mg, 1.67 mmol) in isopropyl alcohol for 8 hours. Cool the solution, collect the precipitate via filtration and wash with dry ether (3×) to give pure (4-Trifluoromethyl-phenyl)-[7-(2-trifluoromethyl-phenyl)-quinazolin-4-yl]amine (Cmpd 2) HCl salt. Mass spec. 433.1.

Workup

  1. temperatureCool the solution
  2. customcollect the precipitate
  3. filtrationvia filtration
  4. washwash with dry ether (3×)

Sources & evidence

ORD record
ord-987e265efc5c4448800fdf9c8a7b78cf
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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