反应详情

To a suspension of 4-bromo-2-nitro-benzonitrile (2.60 g, 0.0115 mol) in 12N HCl at 0° C., add SnCl2-2H2O portionwise. As the reaction is stirred vigorously, a white precipitate will form. After 1 h add ice to the reaction vessel followed by 10N NaOH until the solution is basic. Extract the aqueous mixture with ether (2×) and EtOAc (1×) and wash the combined organic layers with brine. Dry the solution (Na2SO4) and remove the solvents under reduced pressure to give 2-amino-4-bromo-benzonitrile as a beige solid.

1. customa white precipitate will form
2. additionAfter 1 h add ice to the reaction vessel
3. extractionExtract the aqueous mixture with ether (2×) and EtOAc (1×)
4. washwash the combined organic layers with brine
5. dry with materialDry the solution (Na2SO4)
6. customremove the solvents under reduced pressure