HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 968575Generated: October 30, 2026
2-(4-Bromo-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine → 2-Nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzonitrile
https://huagongshe.com/reaction/968575
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(4-Bromo-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine | HCID 22030196 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 2-Nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzonitrile | HCID 22030063 | — |
Reaction Steps
To a solution of 2-(4-bromo-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine (0.55 mmol) in DMA (4 mL) add CuCN (0.60 mmol). Stir the mixture 4 hours at 110° C. Cool to room temperature, dilute with 20 ml of EtOAc, and filter through celite pad. Wash the filtrated with brine, dry over Na2SO4, concentrate under vacuum, and purify by flash chromatography (1:1 hexanes/EtOAc) to give 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07304059B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-227a52b2d2cd486faa6f72a819ab6671 |
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| Source note | uspto-grants-2007_12 |
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