反应详情

温度

110 °C

To a solution of 2-(4-bromo-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine (0.55 mmol) in DMA (4 mL) add CuCN (0.60 mmol). Stir the mixture 4 hours at 110° C. Cool to room temperature, dilute with 20 ml of EtOAc, and filter through celite pad. Wash the filtrated with brine, dry over Na2SO4, concentrate under vacuum, and purify by flash chromatography (1:1 hexanes/EtOAc) to give 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzonitrile.

1. temperatureCool to room temperature
2. filtrationfilter through celite pad
3. washWash the
4. filtrationfiltrated with brine
5. dry with materialdry over Na2SO4
6. concentrationconcentrate under vacuum
7. custompurify by flash chromatography (1:1 hexanes/EtOAc)