HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide | HCID 22030074 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide | HCID 22030471 | — |
Reaction Steps
To a solution of 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (0.5 mmol) and pyridine (0.55 mmol) in THF (5 ml) add acetyl chloride (0.55 mmol). Stir the mixture 10 minutes at room temperature. Concentrate under vacuum, extract with EtOAc, wash with brine, dry over Na2SO4, and concentrate under vacuum. Triturate with ether to give 2-acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304059B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-d0cf7ec725ee4910a3ec55156def5757 |
| Source note | uspto-grants-2007_12 |