2-Acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide → HCID 178433407, compound

HRID 968581Notes

Reaction equation

HRID 968581 reaction equation
[C:1]([NH:4][C:5]1[CH:13]=[C:12]([C:14]2[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:11]=[CH:10][C:6]=1[C:7]([NH2:9])=[O:8])(=O)[CH3:2]>[OH-].[Na+]>[CH3:2][C:1]1[N:9]=[C:7]([OH:8])[C:6]2[C:5](=[CH:13][C:12]([C:14]3[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:11][CH:10]=2)[N:4]=1

Participants

3

Reactant 1

HCID 220304712-Acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Product 1

HCID 178433407HCID 178433407, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Suspend 2-acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide in 20 ml of 20% NaOH, stir for 30 minutes at room temperature. Filter, acidify to pH=6, extract with EtOAc, and concentrate under vacuum to give 2-methyl-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol.

Workup

  1. filtrationFilter
  2. extractionextract with EtOAc
  3. concentrationconcentrate under vacuum

Sources & evidence

ORD record
ord-39340a5ce0cd49718b3616297db0aac2
Source dataset
uspto-grants-2007_12
Patent number
US07304059B2

Reaction notes

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