Chloroform → 6-(Pyridin-3-yloxy)-hexylamine

HRID 968632Notes

Reaction equation

HRID 968632 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1.[OH-].[Na+].C(Cl)(Cl)Cl>O>[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 1317266993-[6-Amino-1-hexyl-oxy]-pyridine, hydrochloride

Product 1

HCID 231324436-(Pyridin-3-yloxy)-hexylamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-[6-amino-1-hexyl-oxy]-pyridine, hydrochloride in water was made strongly alkaline with sodium hydroxide and ectracted twice with chloroform. The organic phase was dried and evaporated in vacuo to yield an oil which was used in the next step without further purification.

Workup

  1. customThe organic phase was dried
  2. customevaporated in vacuo
  3. customto yield an oil which
  4. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-400a87ef9ff74a5ebd328dac00c7c395
Source dataset
uspto-grants-2007_12
Patent number
US07304066B2

Reaction notes

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