反应详情

Imidazole (70 mg) and 1.4 M sodium methoxide (1 ml) were added to N,N-dimethylformamide (3 ml) and the mixture was stirred at room temperature for 30 minutes. A solution of N-(tert-butoxycarbonyl)-6-bromo-hexylamine (280 mg) in N,N-dimethylformamide (1 ml) was added and after heating at 80-90° C. for 30 minutes stirring was continued overnight at room temperature. Evaporation in vacuo followed by stirring with acetone and fitration gave a filtrate which after evaporation was purified by chromatography on silica gel with ethyl acetate/methanol (4:1) as eluent to yield the title compound as a colourless oil.

1. temperatureafter heating at 80-90° C. for 30 minutes
2. stirringstirring
3. waitwas continued overnight at room temperature
4. customEvaporation in vacuo
5. stirringby stirring with acetone and fitration
6. customgave a filtrate which
7. customafter evaporation
8. customwas purified by chromatography on silica gel with ethyl acetate/methanol (4:1) as eluent