反应详情

温度

100 °C

To a suspension of 3-(2-phenylamino-pyrimidin-4-yl)-benzonitrile (10 g, 36.7 mmol) in acetic acid (20 mL) was added concentrated hydrochloric acid (30 mL) and the suspension was heated at 100° C. overnight. The starting material completely dissolved and then a solid precipitated. The reaction mixture was filtered and precipitate was washed with ether and methanol to afford 9 g (84%) of the title compound.

1. dissolutionThe starting material completely dissolved
2. customa solid precipitated
3. filtrationThe reaction mixture was filtered
4. washprecipitate was washed with ether and methanol