反应详情

The suspension of 6-methyl-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carbonitrile (1.47 g, 7.93 mmol) in POCl3 (25 mL) was heated under refluxing for 2 hrs. After cooling to room temperature, the reaction mixture was quenched with ice water and basified with NH4OH followed by extraction with AcOEt. The organic layer was washed with brine and dried over NaSO4, and concentrated to give 4-chloro-6-methyl-[1,5]naphthyridine-3-carbonitrile as a brown solid (0.92 g, 57.1%). HR-MS-EI (+) m/e calcd for C10H6ClN3 (M+) 203.0250. found 203.0252.

1. temperaturewas heated
2. temperatureunder refluxing for 2 hrs
3. customthe reaction mixture was quenched with ice water
4. extractionfollowed by extraction with AcOEt
5. washThe organic layer was washed with brine
6. dry with materialdried over NaSO4
7. concentrationconcentrated