反应详情

The suspension of 4-hydroxy-6-methyl-[1,5]naphthyridine-3-carboxylic acid ethyl ester (4.15 g, 17.87 mmol) in 10% KOH (40 mL) was stirred at room temperature for 3.5 hrs. 3 N HCl was added to adjust the pH to 7. The solid was collected by filtration to give 4-hydroxy-6-methyl-[1,5]naphthyridine-3-carboxylic acid (2.58 g, 72%). HR-ES (+) m/e calcd for C10H8N2O3 (M+H) 205.0608. found 205.0608.

1. filtrationThe solid was collected by filtration