Hydrochloric Acid → HCID 178423371, compound

HRID 968736Notes

Reaction equation

HRID 968736 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[OH:16])=[N:13][C:12]([CH3:17])=[CH:11][CH:10]=2)=[O:5])C.Cl>[OH-].[K+]>[OH:16][C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:17])[N:13]=2)[N:8]=[CH:7][C:6]=1[C:4]([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178469545HCID 178469545, compound

Product 1

HCID 178423371HCID 178423371, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

The suspension of 4-hydroxy-6-methyl-[1,5]naphthyridine-3-carboxylic acid ethyl ester (4.15 g, 17.87 mmol) in 10% KOH (40 mL) was stirred at room temperature for 3.5 hrs. 3 N HCl was added to adjust the pH to 7. The solid was collected by filtration to give 4-hydroxy-6-methyl-[1,5]naphthyridine-3-carboxylic acid (2.58 g, 72%). HR-ES (+) m/e calcd for C10H8N2O3 (M+H) 205.0608. found 205.0608.

Workup

  1. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-7285c5baa308463ab7dbcd78ac32fad9
Source dataset
uspto-grants-2007_12
Patent number
US07304074B2

Reaction notes

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