HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3,4-Dichlorophenoxy)-1-piperidinepropanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propylcarbamate | HCID 11188863 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(3,4-Dichlorophenoxy)-1-piperidinepropanamine | HCID 11324126 | 73.2% |
Reaction Steps
The product from Step (a) (2 g) was dissolved in dioxane (100 ml) and 6N HCl (100 ml) added. After 18 hours at room temperature the solvent was evaporated and the resultant solid basified with NaOH (2N) to pH 11. The aqueous was extracted with ethyl acetate, the organic phase separated, dried with MgSO4 and evaporated to leave the sub-title compound as an oil (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304077B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-89244a74a28e4c15b487870f96801c8d |
| Source note | uspto-grants-2007_12 |