3-Aminobenzoic Acid → 3-Amino-N-[2-[4-(3,4-dichlorophenoxy)-1-piperidinyl]ethyl]benzamide

HRID 968768Notes

Reaction equation

HRID 968768 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][NH2:14])[CH2:8][CH2:7]1.[NH2:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](O)=[O:24]>>[NH2:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23]([NH:14][CH2:13][CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([Cl:18])=[C:2]([Cl:1])[CH:3]=2)[CH2:11][CH2:10]1)=[O:24]

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 113582094-(3,4-Dichlorophenoxy)-1-piperidineethanamine

Product 1

HCID 695229543-Amino-N-[2-[4-(3,4-dichlorophenoxy)-1-piperidinyl]ethyl]benzamide

Procedure

Prepared in a similar manner to the method of Example 14, Step b using the product from Example 3, Step b and 3-aminobenzoic acid to give the sub-title product (0.183 g).

Workup

  1. customPrepared in a similar manner to the method of Example 14, Step b

Sources & evidence

ORD record
ord-e35b50389acf4fb9adb50b8589e33b36
Source dataset
uspto-grants-2007_12
Patent number
US07304077B2

Reaction notes

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