反应详情

A mixture of 6-(Formylamino)-7-methyl-1H-benzimidazole-4-carboxamide (11) (0.35 g, 1.6 mmol), 1M aqueous HCl (10 mL) and methanol (3 mL) is heated to reflux for about 1 hour. The reaction mixture is allowed to cool to ambient temperature and is then concentrated in vacuo to a white solid. The white solid is recrystallized from ethanol/water (3/1 v/v) to provide 6-(Amino)-7-methyl-1H-benzimidazole-4-carboxamide; hydrochloric acid salt (12) as a white solid (0.164 g, 54% Yield).

1. temperatureis heated
2. temperatureto reflux for about 1 hour
3. concentrationis then concentrated in vacuo to a white solid
4. customThe white solid is recrystallized from ethanol/water (3/1 v/v)