Hydrochloric Acid → HCID 178430527, compound

HRID 968804Notes

Reaction equation

HRID 968804 reaction equation
C([NH:3][C:4]1[CH:5]=[C:6]([C:14]([NH2:16])=[O:15])[C:7]2[N:11]=[CH:10][NH:9][C:8]=2[C:12]=1[CH3:13])=O.Cl>CO>[NH2:3][C:4]1[CH:5]=[C:6]([C:14]([NH2:16])=[O:15])[C:7]2[N:11]=[CH:10][NH:9][C:8]=2[C:12]=1[CH3:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178430695HCID 178430695, compound

Product 1

HCID 178430527HCID 178430527, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6-(Formylamino)-7-methyl-1H-benzimidazole-4-carboxamide (11) (0.35 g, 1.6 mmol), 1M aqueous HCl (10 mL) and methanol (3 mL) is heated to reflux for about 1 hour. The reaction mixture is allowed to cool to ambient temperature and is then concentrated in vacuo to a white solid. The white solid is recrystallized from ethanol/water (3/1 v/v) to provide 6-(Amino)-7-methyl-1H-benzimidazole-4-carboxamide; hydrochloric acid salt (12) as a white solid (0.164 g, 54% Yield).

Workup

  1. temperatureis heated
  2. temperatureto reflux for about 1 hour
  3. concentrationis then concentrated in vacuo to a white solid
  4. customThe white solid is recrystallized from ethanol/water (3/1 v/v)

Sources & evidence

ORD record
ord-0640b0b1cf2a481b80016da5aff05eb7
Source dataset
uspto-grants-2007_12
Patent number
US07304084B2

Reaction notes

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