HCID 10052201, compound → HCID 10324256, compound

HRID 968865Notes

Reaction equation

HRID 968865 reaction equation
[CH2:1]([C@@:5]1([C:34]([OH:36])=[O:35])[CH2:9][C@H:8]([CH2:10][O:11][CH2:12][CH:13]=[CH2:14])[C@H:7]([C:15]2[S:16][CH:17]=[CH:18][N:19]=2)[N:6]1[C:20](=[O:33])[C:21]1[CH:26]=[CH:25][C:24]([C:27]([CH3:30])([CH3:29])[CH3:28])=[C:23]([O:31][CH3:32])[CH:22]=1)[CH:2]([CH3:4])[CH3:3].[H][H]>C(O)C.[Pd]>[CH2:1]([C@@:5]1([C:34]([OH:36])=[O:35])[CH2:9][C@H:8]([CH2:10][O:11][CH2:12][CH2:13][CH3:14])[C@H:7]([C:15]2[S:16][CH:17]=[CH:18][N:19]=2)[N:6]1[C:20](=[O:33])[C:21]1[CH:26]=[CH:25][C:24]([C:27]([CH3:28])([CH3:30])[CH3:29])=[C:23]([O:31][CH3:32])[CH:22]=1)[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 10052201HCID 10052201, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10324256HCID 10324256, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of Example 40 (10 mg) in ethanol (4 mL) was added to 10% palladium on carbon (50 mg) and stirred under 1 atmosphere pressure of hydrogen at 20 degrees for 4 h. Catalyst was removed by filtration and washed with ethanol (10 mL). Filtrate and washings were combined and solvent was removed to give the title compound.

Workup

  1. customCatalyst was removed by filtration
  2. washwashed with ethanol (10 mL)
  3. customsolvent was removed

Sources & evidence

ORD record
ord-45d77f471e6f4d698a46d8710f5d3463
Source dataset
uspto-grants-2007_12
Patent number
US07304087B2

Reaction notes

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