反应详情

The crude 3-methyl-benzoic acid tert-butyl ester was reacted with NBS (0.31 g, 1.726 mmol), AIBN (0.28 g, 1.726 mmol) in CCl4 (30 mL) according to the procedure for the preparation of compound 55 in example 1. After separation by chromatography eluted with CHCl3—MeOH (50:1), a mixture of two products was obtained. One of them was the product (61% pure) with MS (ESI) 272.76 (M+H+). This mixture was not further separated and directly used in the next step reaction.

1. customAfter separation by chromatography
2. washeluted with CHCl3—MeOH (50:1)
3. additiona mixture of two products
4. customwas obtained
5. customThis mixture was not further separated
6. customdirectly used in the next step reaction