Lithium hydroxide, monohydrate → HCID 11566810, compound

HRID 969005Notes

Reaction equation

HRID 969005 reaction equation
C([O:5][C:6]([C:8]1([CH2:13][CH2:14][CH2:15][CH2:16][C:17](=[O:34])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]2([C:27]([O:29]CCCC)=[O:28])[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7])CCC.O[Li].O>>[C:27]([C:22]1([CH2:21][CH2:20][CH2:19][CH2:18][C:17](=[O:34])[CH2:16][CH2:15][CH2:14][CH2:13][C:8]2([C:6]([OH:7])=[O:5])[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:23][CH2:24][CH2:25][CH2:26]1)([OH:29])=[O:28]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 21069429HCID 21069429, compound

Product 1

HCID 11566810HCID 11566810, compoundYield 99.3%

Procedure

Compound 107g was prepared likewise Method D starting from 106g (7.25 g, 15.0 mmol) and LiOH.H2O (3.21 g, 76.4 mmol) to give 107g (5.46 g, 95% pure by 1H NMR, 94%, mp=99-103° C.) as a white solid. An analytical sample was obtained after recrystallization from iPr2O/heptane. mp=104-106° C. 1H NMR: δ 2.39 (t, J=6.9 Hz, 4H), 2.18-2.10 (m, 4H), 1.69-141 (m, 20H), 1.27-1.14 (m, 4H). 3C NMR: δ 211.1, 184.6 (2×), 53.9 (2×), 42.5 (2×), 39.0 (2×), 35.9 (4×), 25.7 (2×), 24.9 (4×), 24.0 (2×). Anal. calcd for C21H34O5: C, 68.82; H, 9.35, found: C, 68.78; H, 9.47.

Workup

  1. customCompound 107g was prepared likewise Method D

Sources & evidence

ORD record
ord-b86b95c502674155910988847ee4453d
Source dataset
uspto-grants-2007_12
Patent number
US07304093B2

Reaction notes

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