Trifluoroacetic acid → HCID 66662243, compound

HRID 969159Notes

Reaction equation

HRID 969159 reaction equation
O[C:2]1([C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[Al]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH:4]1[CH2:5][CH:6]=[C:2]([C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[CH2:3]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 5359268AluminumHCID 59298225HCID 59298225, compound

Product 1

HCID 66662243HCID 66662243, compound

Procedure

tert-Butyl 3-hydroxy-3-(1,3-thiazol-2-yl)pyrrolidine-1-carboxylate (1.0 g, 0.0037 mol) was dissolved in trifluoroacetic acid (10.0 mL, 0.130 mol) under N2 at rt. The reaction flask was wrapped with aluminum foil and the mixture was stirred under reflux for 3 h. After cooling to rt the reaction mixture was concentrated in vacuo and used directly for the next step without further purification.

Workup

  1. temperatureunder reflux for 3 h
  2. concentrationwas concentrated in vacuo
  3. customused directly for the next step without further purification

Sources & evidence

ORD record
ord-b1aed15b62d44f69a02e0520bf8f1d6f
Source dataset
uspto-grants-2007_12
Patent number
US07304081B2

Reaction notes

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