Methanol → HCID 66662131, compound

HRID 969160Notes

Reaction equation

HRID 969160 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH2:12][CH:11]=[C:10]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[CH2:9]1.CO>[Pt](=O)=O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 887MethanolHCID 66662243HCID 66662243, compound

Product 1

HCID 66662131HCID 66662131, compound

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

To a solution of 2-(2,5-dihydro-1H-pyrrol-3-yl)-1,3-thiazole trifluoroacetate (2.49 g, 0.00936 mol) in methanol (100.0 mL, 2.469 mol) was added platinum dioxide (320 mg, 0.0014 mol) and the resulting mixture was hydrogenated on par shaker at 56 psi for 3 h. After filtration, the filtrate was concentrated in vacuo and dried under high vacuum to give the desired product as a solid. LC-MS (M+H) 155.2 (base).

Workup

  1. filtrationAfter filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-ba691a03bacd414cb76f157925ac683c
Source dataset
uspto-grants-2007_12
Patent number
US07304081B2

Reaction notes

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