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HRID969403

反应详情

EQUATION

反应方程式

HRID 969403 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCCCC1CCNCC1
HCID13283867

4-Butylpiperidine

C9H19N

结构：Cc1ccc2c(c1)N(C[C@H](C)CI)C(=O)CO2
HCID68908548

未命名化合物

PRODUCTS

生成物

1
结构：CCCCC1CCN(C[C@@H](C)CN2C(=O)COc3ccc(C)cc32)CC1
HCID68910076

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O.CO.ClCCl
溶剂HCID21584259

未命名化合物

PROCEDURE

实验过程

Crude (S)-4-(3-iodo-2-methylpropyl)-6-methyl-4H-benzo[1,4]oxazin-3-one (0.30 g), Et3N (0.5 mL) and 4-butylpiperidine (0.15 g, 1.0 mmol) were reacted according to GP17. Flash CC (SiO2; CH2Cl2/acetone/MeOH 90:7:3) gave the title compound (0.26 g, 84%). 1H NMR (CD3OD) δ 7.00 (s, 1H), 6.86 (d, J=8.0 Hz, 1H), 6.81 (dm, J=8.0 Hz, 1H), 4.52 (ABq, J=14.4, 20.8 Hz, 2H), 3.99 (dd, J=6.0, 14.4 Hz, 1H), 3.90 (dd, J=8.4, 14.4 Hz, 1H), 2.97 (brd, J=11.2 Hz, 1H), 2.82 (brd, J=8.4 Hz, 1H), 2.39-2.10 (m, 2H), 2.31 (s, 3H), 2.07-1.88 (m, 2H), 1.73-1.62 (m, 2H), 1.35-1.18 (m, 9H), 0.94-0.08 (m, 6H); 13C NMR (CD3OD) δ 166.0, 143.8, 132.4, 128.3, 124.3, 116.6, 116.2, 67.4, 63.6, 55.0, 54.2, 44.8, 36.2, 35.6, 32.1 (br), 28.9, 28.8, 22.8, 20.0, 15.9, 13.2.