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HRID969405

反应详情

EQUATION

反应方程式

HRID 969405 的结构方程式

REACTANTS

反应物

2
结构：CCCCCC1CC2CCC(C1)N2
HCID21989852

未命名化合物

结构：Cc1ccc2c(c1)N(C[C@H](C)CI)C(=O)CO2
HCID68908548

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCC1CC2CCC(C1)N2C[C@@H](C)CN1C(=O)COc2ccc(C)cc21
HCID68915188

未命名化合物

收率 69.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Crude (S)-4-(3-Iodo-2-methylpropyl)-6-methyl-4H-benzo[1,4]oxazin-3-one (0.15 g), Et3N (0.5 mL) and 3-pentyl-8-azabicyclo[3.2.1]octane (95 mg, 5.2 mmol) were reacted according to GP17. Flash CC (SiO2; CH2Cl2/I-PrOH 92:8) gave the title compound (0.12 g, 68%). 1H NMR (CD3OD) δ 7.06 (s, 1H), 6.86 (d, J=8.0 Hz, 1H), 6.81 (brd, J=8.0 Hz, 1H), 4.52 (ABq, J=14.8, 27.2 Hz, 2H), 4.06 (dd, J=5.6, 14.2 Hz, 1H), 4.96 (dd, J=8.8, 14.2 Hz, 1H), 3.16-3.02 (m, 2H), 2.34-2.07 (m, 7H), 2.31(s, 3H), 2.04-1.81 (m, 3H), 1.70-1.55 (m, 3H), 1.46-1.21 (m, 10H), 0.92-0.85 (m, 6H); 13C NMR (CD3OD) δ 167.2, 145.1, 133.6, 129.4, 125.5, 117.7, 117.5, 68.7, 61.6, 60.2, 58.6, 46.1, 39.6, 37.2, 36.9, 33.1, 32.4, 29.6, 29.5, 28.5, 27.8, 23.7, 21.18, 17.0, 14.4.