2-(4-Methoxyphenyl)-1,1-dimethylethylamine → HCID 69462583, compound

HRID 969462Notes

Reaction equation

HRID 969462 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]2[CH2:22][O:21]2)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]([NH2:35])([CH3:34])[CH3:33])=[CH:27][CH:26]=1>C(O)CCC>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]([OH:21])[CH2:22][NH:35][C:32]([CH3:34])([CH3:33])[CH2:31][C:28]2[CH:29]=[CH:30][C:25]([O:24][CH3:23])=[CH:26][CH:27]=2)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 918922-(4-Methoxyphenyl)-1,1-dimethylethylamineHCID 138976418-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one

Product 1

HCID 69462583HCID 69462583, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

587 mg (2 mmol) 8-benzyloxy-5-oxiranyl-1H-quinolin-2-one and 358 mg (2 mmol) 2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamine are stirred in 5 mL n-butanol for 6 hours at 140° C. Then the solvent is distilled off and the residue is purified by chromatography (reverse phase; water/acetonitrile gradient).

Workup

  1. distillationThen the solvent is distilled off
  2. customthe residue is purified by chromatography (reverse phase; water/acetonitrile gradient)

Sources & evidence

ORD record
ord-a8eddcc46d5c4e5f830835763cf262fc
Source dataset
uspto-grants-2007_12
Patent number
US07307076B2

Reaction notes

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