HCID 69462583, compound → HCID 11531056, compound

HRID 969463Notes

Reaction equation

HRID 969463 reaction equation
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]([OH:35])[CH2:21][NH:22][C:23]([CH3:34])([CH3:33])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]([OH:35])[CH2:21][NH:22][C:23]([CH3:33])([CH3:34])[CH2:24][C:25]2[CH:26]=[CH:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=2)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2

Participants

4

Reactant 1

HCID 69462583HCID 69462583, compound

Product 1

HCID 11531056HCID 11531056, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

306 mg (0.6 mmol) 8-benzyloxy-5-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one are dissolved in 10 mL methanol and hydrogenated with palladium on charcoal as catalyst at ambient temperature and normal pressure. Then the catalyst is separated off and the filtrate is freed from the solvent.

Workup

  1. customThen the catalyst is separated off

Sources & evidence

ORD record
ord-dd736a9fb4884813b26c9d91eba5ceee
Source dataset
uspto-grants-2007_12
Patent number
US07307076B2

Reaction notes

Loading…