2-(4-Methoxyphenyl)-1,1-dimethylethylamine → 5-benzyloxy-8-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethylimino]-ethyl}-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one

Participants

Reaction Steps

10.1 g (26 mmol) 5-benzyloxy-8-(2-ethoxy-2-hydroxy-acetyl)-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one and 4 g (22 mmol) 2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamine are stirred in 100 ml of ethanol for 2 hours at 60 to 70° C. After some of the solvent has been distilled off a solid is precipitated out during cooling, and this is suction filtered and washed with ethanol and diethyl ether.

Provenance & Evidence