Phosphoric Acid → HCID 69135072, compound

HRID 969489Notes

Reaction equation

HRID 969489 reaction equation
P(=O)(O)(O)O.[CH2:6]([O:8][C:9]([C:11]1[C:21]([CH2:22][CH2:23][CH:24](O)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:20]([OH:32])[C:14]2[N:15]=[C:16]([CH3:19])[N:17]([CH3:18])[C:13]=2[CH:12]=1)=[O:10])[CH3:7].[OH-].[Na+]>>[CH2:6]([O:8][C:9]([C:11]1[C:21]2[CH2:22][CH2:23][CH:24]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[O:32][C:20]=2[C:14]2[N:15]=[C:16]([CH3:19])[N:17]([CH3:18])[C:13]=2[CH:12]=1)=[O:10])[CH3:7]

Participants

4

Reactant 3

HCID 1004Phosphoric AcidHCID 14798Sodium HydroxideHCID 69135242HCID 69135242, compound

Product 1

HCID 69135072HCID 69135072, compoundYield 86%

Procedure

42 ml Phosphoric acid (85%) and 4.2 g (11.4 mmol) 7-hydroxy-6-(3-hydroxy-3-phenyl-propyl)-2,3-di-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester were heated at 80° C. for 2 h. After cooling to room temperature the reaction mixture was poured into ice-water and neutralized with 10 N sodium hydroxide solution. The precipitate was filtered off and dried in vacuo at 40° C. to afford 3.4 g (86%) of the title compound as a white solid. m. p. 172°-173° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-4b5be605a2d044008b91c7324ae0f48e
Source dataset
uspto-grants-2007_12
Patent number
US07307084B2

Reaction notes

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