Phosphoric Acid → HCID 69135072, compound

Participants

Reaction Steps

42 ml Phosphoric acid (85%) and 4.2 g (11.4 mmol) 7-hydroxy-6-(3-hydroxy-3-phenyl-propyl)-2,3-di-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester were heated at 80° C. for 2 h. After cooling to room temperature the reaction mixture was poured into ice-water and neutralized with 10 N sodium hydroxide solution. The precipitate was filtered off and dried in vacuo at 40° C. to afford 3.4 g (86%) of the title compound as a white solid. m. p. 172°-173° C.

Provenance & Evidence