Hydrochloric Acid → HCID 23102724, compound

HRID 969546Notes

Reaction equation

HRID 969546 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2([CH3:25])[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1.[ClH:30]>C(O)C>[ClH:1].[ClH:30].[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12]2([CH3:25])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 23102773HCID 23102773, compound

Product 1

HCID 23102724HCID 23102724, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1,1-Dimethylethyl 4-(3,4-dichlorophenoxy)-4′-methyl-[1,4′-bipiperidine]-1′-carboxylate (100 mg) was dissolved in ethanol (5 ml). Hydrogen chloride (2 ml of 4M in dioxan) was added and the solution was stirred overnight. Further hydrogen chloride solution (2 ml) was added and the mixture was stirred for a further 2 h. The solvents were evaporated to give the title compound (95 mg; MS [M+H]+ (APCI+) 343/345).

Workup

  1. stirringthe mixture was stirred for a further 2 h
  2. customThe solvents were evaporated

Sources & evidence

ORD record
ord-e4159d02ac2847cea8b93d3349b58c96
Source dataset
uspto-grants-2007_12
Patent number
US07307090B2

Reaction notes

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