Indole → HCID 11243165, compound

HRID 969600Notes

Reaction equation

HRID 969600 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 798IndoleHCID 74014-Methoxybenzenesulfonyl chloride

Product 1

HCID 11243165HCID 11243165, compoundYield 95%

Procedure

The title compound was prepared from 4-methoxy-benzene sulfonyl chloride and 1H-indole, according to Method A, described above. Yield 95%; mp 124-126° C.; 1H NMR (CDCl3) δ 7.90-7.93 (dd, J=8 Hz, 1H), 7.74 (d, J=9 Hz, 2H), 7.43-7.49 (m, 2H), 7.14-7.27 (m, 2H), 6.79 (d, J=9 Hz, 2H), 6.56-6.58 (dd, J=4 Hz, 1H), 3.41 (s, 3H); 13C NMR (CDCl3) δ 164.1, 135.2, 131.2, 130.1, 129.5, 126.7, 124.9, 123.6, 121.8, 114.8, 113.9, 109.3, 56.0; MS (AP+) m/z288.05 (M++1).

Sources & evidence

ORD record
ord-1a544e9b25cc45c3a46375d739fa7811
Source dataset
uspto-grants-2007_12
Patent number
US07307099B2

Reaction notes

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