Indole → HCID 10590848, compound

HRID 969602Notes

Reaction equation

HRID 969602 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1)(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 798IndoleHCID 71252-Naphthalenesulfonyl chloride

Product 1

HCID 10590848HCID 10590848, compoundYield 92%

Procedure

The title compound was prepared from naphthalene-2-sulfonyl chloride and 1H-indole, according to Method A, described above. Yield 92%; mp 103-105° C.; 1H NMR (CDCl3) δ 8.33-8.34 (m, 1H), 7.85-7.89 (dd, J=8 Hz, 1H), 7.69-7.76 (m, 1H), 7.52-7.64 (m, 3H), 7.29-7.46 (m, 4H), 6.97-7.24 (m, 2H), 6.46-6.48 (dd, J=4 Hz, 1H); 13C NMR (CDCl3) δ 135.6, 135.5, 135.3, 132.3, 131.2, 130.1, 129.8, 128.9, 128.3, 128.2, 126.8, 125.1, 123.8, 121.9, 121.8, 113.9, 109.7; MS (AP+) m/z 308.04 (M++1).

Sources & evidence

ORD record
ord-504780921b40474981938ae1b8d6f270
Source dataset
uspto-grants-2007_12
Patent number
US07307099B2

Reaction notes

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