Indole → 1-(2,4,6-Triisopropyl-benzenesulfonyl)-1H-indole

HRID 969604Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[C:6]([CH:13]([CH3:15])[CH3:14])[C:5]=1[S:16](Cl)(=[O:18])=[O:17])([CH3:3])[CH3:2].[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21]1>>[CH:1]([C:4]1[CH:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[C:6]([CH:13]([CH3:15])[CH3:14])[C:5]=1[S:16]([N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21]1)(=[O:18])=[O:17])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 798Indole

HCID 810422,4,6-Tris(1-methylethyl)benzenesulfonyl chloride

Product 1

HCID 113036341-(2,4,6-Triisopropyl-benzenesulfonyl)-1H-indoleYield 88%

Procedure

The title compound was prepared from 2,4,6-triisopropyl-benzene sulfonyl chloride and 1H-indole, according to Method A, described above. Yield 88%; mp 131-133° C.; 1H NMR (CDCl3) δ 7.41-7.65 (m, 3H), 7.18-7.28 (m, 4H), 6.65-6.68 (dd, J=8 Hz, 1H), 4.15-4.31 (m, 2H), 2.81-2.97 (m, 1H), 1.28 and 1.29 (2s, 6H), 0.98-1.12 (m, 12H).

Sources & evidence

ORD record: ord-8c5cf090011848ca87ff0beaabfd4a5e
Source dataset: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07307099B2

Reaction notes

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