HCID 69510346, compound → HCID 69510665, compound

HRID 969663Notes

Reaction equation

HRID 969663 reaction equation
[N+:1]([C:4]1[CH:28]=[CH:27][CH:26]=[CH:25][C:5]=1[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:24])([CH:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[CH3:16])=[CH:11][CH:10]=1)=[O:7])([O-])=O.[H][H]>CCO.[Pd]>[NH2:1][C:4]1[CH:28]=[CH:27][CH:26]=[CH:25][C:5]=1[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([CH3:24])([CH:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]2)[CH3:16])=[CH:13][CH:14]=1)=[O:7]

Participants

5

Reactant 2

HCID 69510346HCID 69510346, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69510665HCID 69510665, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-Nitro-N-{4-[1-methyl-1-(1-methylpiperidin-4-yl)ethyl]phenyl}benzamide (Step A, 750 mg) was mixed with Pd/C (10%, 200 mg) in EtOH (80 mL) and hydrogenated under a hydrogen atmosphere for 1 h. The solution was filtered through Celite® and evaporated to give the amine used in the next step without further purification.

Workup

  1. filtrationThe solution was filtered through Celite®
  2. customevaporated

Sources & evidence

ORD record
ord-0cf36382da0a4803a0b6bb785fa0e214
Source dataset
uspto-grants-2007_12
Patent number
US07307088B2

Reaction notes

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