4-(1,1-Dimethoxyethyl)pyrimidin-2-amine → 1-(2-Aminopyrimidin-4-yl)ethan-1-one

HRID 969699Notes

Reaction equation

HRID 969699 reaction equation
C[O:2][C:3]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=1)(OC)[CH3:4]>C(O)=O>[NH2:13][C:9]1[N:8]=[C:7]([C:3](=[O:2])[CH3:4])[CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 1

HCID 135822684-(1,1-Dimethoxyethyl)pyrimidin-2-amine

Product 1

HCID 135822701-(2-Aminopyrimidin-4-yl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

To 4-(1,1-dimethoxy-ethyl)-pyrimidin-2-ylamine (Step A, 15 g, 81.87 mmol) was added HCOOH (70.0 mL). The resulting mixture was stirred at RT under argon for 3 h. The mixture was evaporated to dryness. The solid was recrystallized from EtOH to give a brown solid. MS m/z:138.2(M+H). Calc'd for C6H8N3O: 138.14.

Workup

  1. customThe mixture was evaporated to dryness
  2. customThe solid was recrystallized from EtOH
  3. customto give a brown solid

Sources & evidence

ORD record
ord-50ad7417d71c4cf89b8701774ce486b6
Source dataset
uspto-grants-2007_12
Patent number
US07307088B2

Reaction notes

Loading…