4-(1,1-Dimethoxyethyl)pyrimidin-2-amine → 1-(2-Aminopyrimidin-4-yl)ethan-1-one

Participants

Reaction Steps

To 4-(1,1-dimethoxy-ethyl)-pyrimidin-2-ylamine (Step A, 15 g, 81.87 mmol) was added HCOOH (70.0 mL). The resulting mixture was stirred at RT under argon for 3 h. The mixture was evaporated to dryness. The solid was recrystallized from EtOH to give a brown solid. MS m/z:138.2(M+H). Calc'd for C6H8N3O: 138.14.

Provenance & Evidence