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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9697Generated: October 26, 2026

Ethyl (4-hydroxy-2-methylphenoxy)acetate → Ethyl[4-({5-[2,3-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

https://huagongshe.com/reaction/9697

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl (4-hydroxy-2-methylphenoxy)acetateHCID 21986458—
Reactant{5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanolHCID 21986476—
ReactantEthyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetateHCID 21986477—
ProductEthyl[4-({5-[2,3-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetateHCID 21986290—

Reaction Steps

The title compound was prepared by a method analogous to that used for the preparation of ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate (example 1) using ethyl(4-hydroxy-2-methylphenoxy)acetate (intermediate 7) and {5-[2,3-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol (intermediate 122).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-76587a1d5d874959b2ba87d99a8c3da7
Source noteuspto-grants-2006_08